Structure of DNA: An Overview

Structure of DNA: An Overview The structure of DNA Deoxyribonucleic acid or DNA is generally found in all organisms as well as humans. DNA is an inherited material that every person has, and is set up in both the cell nucleus and the mitochondria. A higher percentage of human DNA comprise of nuclear DNA because it is found in the nucleus. (Berger, 1998). DNA comprises of numerous properties, the most significant being; that it can copy itself. In the occurrence of this process, the twofold helix strands of DNA are employed as a model for replicating the base sequences. (Watson, 2011). This is an important process in the event of cell division due to the vital requirement for each new cell to carry an accurate DNA copy found in the mature cell. Adenine (A), guanine (G), thymine (T), cytosine (C) and uracil (U) are major five chemical bases that accumulate DNA’s coded information (Watson Crick, 2003). There are over three billion of such chemicals. More than 99% of these bases have been proved to be reliable in all humans (Buch ini Leumann, 2003). As a result of the complexity and association of the entire DNA structure, an in-depth look of each part; DNA is the genetic information of nearly all living organisms. It can be copied over age brackets of cells; it can be converted into proteins; and can be mended when required. DNA is a polymer, composed of nucleotides (Watson Crick, 2003) Hydrogen bonds: bases pairing The (hydrophobic) bases are piled on the in the interior, their level surface are vertical to the axis of the double helix (Berger, 1998). The exterior (phosphate and sugar) is hydrophilic. Hydrogen limits between the bases of one strand and that of the other strand grip the two strands together (dashed lines in the drawing). A purine on one strand links to a pyrimidine on the other strand. Consequently, the number of purines deposits matches the number of pyrimidine deposits (Watson, 2011). A binds T (with 2 hydrogen bounds), while G binds C (with 3 hydrogen bounds: more stable link: 5.5 kcal vs 3.5 kcal) (Rà ¤dler Safinya, 1997). Thus, the substance in A in the DNA is equal to the one in T, and the substance in G equals the one in C. The complement of the 2 strands is as a result of this (AT and GC) correspondence. One serves as a template of the other, and vice versa. This feature allows exact replication (â€Å"semi-conservative replication: one strand -the template- is conserved, another is newly synthesized, same with the second strand, conserved, allowing another one to be newly synthesized†) (Buchini Leumann, 2003). The model of Watson and Crick above described sometimes differs from the Hydrogen bounds in base pairing from using the N7 atom of the purine instead of the N1 (Hoogsteen model). Figure 1 Major groove and minor groove The double helix is a rather inflexible and thick molecule of a huge extent and a small diameter. It presents both major groove and a minor groove (Patil, Rhodes Burgess, 2004). The major groove is profound and broad; the minor groove is thin and shallow. DNA-protein connections are essential procedures in the life of the cell life. Proteins connect at the ground of the DNA grooves, using a precise binding: hydrogen bounds, and distracted binding: van der Waals exchanges. Proteins recognize H-bond donors, H-bond acceptors, methyl groups (hydrophobic), which are later in the major groove (Rà ¤dler Safinya, 1997). The major groove involves 4 likely patterns of recognition, and 2 with the minor groove. A few proteins bind DNA in its major groove, some other in the minor groove, and some need to bind to both. The minor groove of double helical B-DNA is a sector of great attention for rising new drugs because of its non-covalence high succession specific connections for a huge number of tiny molecules (Berger, 1998). Minor groove binding lies among the broadly studied class of agents exemplified by, an advanced succession specificity and possessing diverse biological actions. A number of them display antiviral, antibacterial, and antiprotozoal properties. However, others have shown antitumor activity. Figure 2 H-DNA or triplex DNA Inverted repeats (palindromes) of polypurine/polypyrimidine DNA stretches can structure triplex structures (triple helix) (Watson Crick, 2003). A triple-stranded together with a single stranded DNA are formed. H-DNA may have a function in practical regulation of gene appearance as well as on RNAs (e.g. repression of transcription). Figure 3 Triplex Forming Nucleotides Triplex forming oligonucleotides (TFOs) have attained significant focus as a possible therapeutic agent to aim gene expression (Patil, Rhodes Burgess, 2004). They are a group of DNA oligonucleotides which are capable of fusing with other main groove of the duplex DNA creating triple helix (Buchini Leumann, 2003). The creation of a triplex beside the main groove leads to competition with the fusing of transcription factors and the proteins essential for transcription. TFOs provide specificity sequence and hence can be used to aim and inhibit appearance of specific genes which are associated with a particular disease state. In addition TFOs can also be used as diagnostic agents for identification of a foreign DNA (viral or bacterial) or any diseases associated to mutations. Binding of Triplex Forming Oligonucleotides TFOs, in the span of approximately 20 bases, can bind in the major groove via Hoogsteen hydrogen bonds to the purine (A and G) bases on the double stranded DNA, already in the structure of the Watson-Crick helix. The binding can take place at the extent of pyrimidines of one DNA strand and the opposite purines on the other. TFOs bind to the strand with purines. Respective of their base composure, TFOs can bind to the double helix in either parallel or antiparallel direction to the purine-bearing strand (Buchini Leumann, 2003). TFOs made of pyrimidines (C and T) bind to the purine-rich strand of the objective double helix via Hoogsteen hydrogen bonds in a parallel manner. TFOs comprised of purines (A and G), or mixed purine and pyrimidine (G and T) bind to the same purine-rich strand through reverse Hoogsteen bonds in an anti-parallel style (Rà ¤dler Safinya, 1997). Oligonucleotides with modified structural features Oligonucleotides hauling other compound moieties besides the normal bases are called â€Å"modified oligonucleotides†. The modifications can be situated at the 3’- or 5’-end of the oligonucleotide, or within the sugar-phosphate stamina or at the nucleobases. Mainly all PCR applications are still potential if the modification is close to the 5’- end of the oligonucleotide. Contrary, modifications at the 3’- end typically wedge this end for extra enzymatic response. In order to achieve an absolute blocking, an inverted end or C3-Spacer modification is recommended (Patil, Rhodes Burgess, 2004). Chemically synthesized oligonucleotides bear free hydroxy (OH) collection at their relevant 3’- and 5’- ends (Berger, 1998). Besides, some biological tests need the presence of the natural structure of an oligonucleotide. This modification requires being ordered explicitly (Rà ¤dler Safinya, 1997). Structure and Limitations DNA triple helices figure in a sequence-specific way on polypurine:polypyrimidine tracts (1–3), which are extensive in mammalian genomes (4–6). The third thread recline in the major groove of an integral duplex and is calmed by two Hoogsteen hydrogen bonds between third strand bases and the purines in the duplex (3, 7) (Buchini Leumann, 2003). The third strand may comprise of pyrimidines, or purines, respective of the character of the target succession. In the pyrimidine (or Y.R:Y) motif, a homopyrimidine oligonucleotide binds in a trend parallel to the purine strand in the duplex, with canonical base triplets of T.A:T and C.G:C. In the alternate purine motif (R.R:Y), a homopurine strand binds antiparallel to the purine strand, with base triplets of A.A:T and G.G:C (8, 9) (Buchini Leumann, 2003). The development of TFOs could involve sequence-specific gene targeting reagents in live cells (12–17) (Berger, 1998). Despite this, several obstacles still need to be overcome. Triplex chemistry and biochemistry inflict essential limitations to TFO action in the nuclear setting, and target choices are inadequate to polypurine:polypyrimidine sequences (Watson, 2011). Additionally, it is evident that nucleosomes can inhibit triplex formation (18–20). As a result, ease of access to genomic targets is an important issue. Potential applications of TFOs-gene targeting Potential applications of TFOs embrace gene targeting treatment particularly for cancer and the study of gene expressions. TFOs can hush a gene record by aiming the dictation initiation sites, (i.e., the promoter region), or by targeting recording of elongation by striking at the triplex binding sites. Specifity of sequence is the answer to efficient genetic targeting. With the use of specificity, genes that are targeted can be changed in many ways. Gene therapy agents change into loose cannons inside the cells without it. Triplex forming oligonucleotides (TFOs) fuse into main groove of the duplex DNA with high affinity and specificity (Watson, 2011). Due to these properties, TFOs have been thought as host devices for the genetic manipulation. Recent researches have shown that TFOs have the ability to mediate targeted gene success in mice, establishing the basis for the possible application of those molecules in a human being’s gene therapy. Molecules that fuse with the DNA double helix might interfere with gene appearance and, to add to the potential therapeutic applications, it can be useful for the research of DNA processing, package of chromatin, or related biological processes. The Triplex-forming oligonucleotides (TFOs) fuse with specific sequences in DNA double helix through hydrogen bonding interactions. The TFOs have been revealed to down-regulate the expression of the gene, to induce aimed genomic DNA modifications, so as to fasten DNA combination, and also to regulate chromatin organization. In addition to this, they can be used as transporting agents to place DNA-modifying agents into selected sequences (Patil, Rhodes Burgess, 2004). Something important regarding TFO technologies are the creation of fresh oligonucleotide analogues which have improved fusing affinity, sufficient stability and better target selectivity, in intracellular environment. References Watson, J. D, Crick, F. H, 2003, The structure of DNA. In Cold Spring Harbor Symposia on Quantitative Biology, Vol. 18, pp. 123-131, Cold Spring Harbor Laboratory Press. Berger, J. M. (1998). Structure of DNA topoisomerases. Biochimica et Biophysica Acta  (BBA)-Gene Structure and Expression, 1400(1), 3-18. Rà ¤dler, J. Safinya, C. R., 1997, Structure of DNA-cationic liposome complexes: DNA  Intercalation in Multilamellar Membranes in Distinct Interhelical Packing Regimes, Science, 275(5301), 810-814. Watson, J. D, 2011, The double helix: A personal account of the discovery of the structure of DNA, Simon and Schuster. Buchini, S., Leumann, C. J, 2003, Recent improvements in antigene technology, Current opinion in chemical biology, 7(6), 717-726. Patil, S. D., Rhodes, D. G., Burgess, D. J, 2004, Anionic liposomal delivery system for DNA transfection, The AAPS journal, 6(4), 13-22.

Ethics in an Academic Environment Essay

Teachers hold the power and responsibility for building the foundations of intellectually and morally great minds. Since people spend a large chunk of their class and their entire formative years in school, their position and contact with young children and adolescents allows they shape and mold what these young people’s potentials and capabilities. Teachers have the opportunity to influence and inspire the future generations. As such, it is imperative that teachers become rightful role models of ethics for their students. Karl Menninger believed that â€Å"What the teacher is, is more important than what he teaches† (cited in Hunter, 2006). Menninger’s statement stress that teachers should always be a good ethical example for their students to look up to and learn from. A teacher must show tact, tolerance and morally-charge decision-making; he or she has to refrain from preferring one student over the other and from demonstrating disrespect or irritation for any of his or her students (Hunter, 2006). In a nutshell, for a teacher to be an ethical one, he or she has to always depict professionalism. Teacher professionalism manifests as both an internal, personal practice and an explicit expression. Professionalism starts from the inside. A teacher needs to make a fundamental commitment to teaching and to all the people that his or her teaching will touch (Phelps, 2003). This commitment is actualized by a teacher’s shown competency in his or her field and his or her capacity for following the teachers’ manual or code of ethics. It is essential that teachers recognize that their accountability should lie first, foremost and only with the students they teach. Therefore, a teacher shows his or her professionalism in how he or she prepares and plans how he or she could impart knowledge to the students in best way possible. Apart from making sure students understand what he or she is teaching to them now will have a high, enduring quality and will have more than just academic significance to students’ lives. To motivate and help them give their best effort every single day and to every single student, Phelps (2003) believes that teachers ought to accept and embrace all the challenges and hardships the journey of educating and aiding the youth’s learning may possess. In doing so, teaching is elevated to more than just a job for teachers but a calling. Professionalism requires teachers to invest themselves physically, mentally and emotionally in the process of the student’s education. This act allows teachers to make personal connections with students. Personal connections, relationships and bonds with one’s students are generally positive and helpful qualities. However, heavy emotional investments can also pave the way for the loss of professionalism, for which personal sentiments were invested in the first place. Emotional investments and personal connections can destroy professionalism and lead to a bending of the credibility of teacher-student ethics when they become the main object of teacher-student relationships instead of one of its reinforcements. When a teacher forms personal opinions or connections with one or a few particular students, it leads to a closeness or familiarity that can affect a teacher’s ethical conduct and professionalism. Examples would be developing a romantic relationship with a student or creating a hierarchy of student’s value based on a personal favoritism. Apart from creating partialities in favor of a student, personal opinions could further cloud a teacher’s judgment and create bias against a student or certain students. In both aspects, the founding of personal opinion can seriously hamper a teacher’s potential to be at his or her most professional best. Teachers are therefore reminded to abide by the code of ethics and ensure the protection of the rights of students, each and every single student (University of Iowa [UI], 2008). Teachers are encouraged to build rapport and make students comfortable in their presence enough for the students to liberally and honestly participate and contribute to class discussions. However, teachers are responsible for ensuring that there is still a professional boundary between them and student to prevent their relationship from getting too casual (UI, 2008). Teachers should instill and model fairness for all students of all racial, ethnical and economic background. Overall, ethics between teachers and students depend on the level of professionalism the teacher has. Teachers’ positions or social roles emphasize respect for one’s profession and the people they encounter. Teachers should direct all of their efforts and prioritize above all how they have contributed to students’ learning and development. References Hunter, D. (2006, Oct. 18). Teacher’s ethics. Articles Base. Retrieved March 13, 2009 from http://www. articlesbase. com/article-marketing-articles/teachers-ethics-64131. html Phelps, P. (2003). Teacher Professionalism. In Find Articles. Retrieved March 13, 2009 from http://findarticles. com/p/articles/mi_qa4009/is_200310/ai_n9335958 University of Iowa. (2008). The importance of teacher ethics. Retrieved March 13, 2009 from http://www. education. uiowa. edu/resources/tep/eportfolio/07e170folder/Ethics. htm

The Prospect Of Building Underwater Environmental Sciences Essay

Population in Egypt increased in the last 10 old ages and reached 80 million with mean one-year growing 2.04 % . Traffic congestion is the largest job that Egypt faces, and it has a great consequence on air quality, going clip, concern, and cost. The authorities ever tries to work out the congestion by constructing new Bridgess, overpasss and metros, but unluckily it fails due to the addition of population. In this study there is a survey on edifice with a new engineering which is constructing underwater. Although submerged edifices exist since 1960 but no 1 have heard about it. Constructing underwater will be advantageous to the environment if people win in accomplishing it. Everything can be built submerged like Houses, hotels, watering place, eating houses aˆÂ ¦ etc. to allow people hold a good life or holiday. The glamour position underwater of fishes, coral reefs and different animals encourages people to construct and populate at that place. This study will discourse the possibility and the advantages of submerged edifices. The first subdivision will specify what submerged edifices are, and demo the advantages and credence of them. The 2nd will discourse the consequence of submerged edifices on the environment. The 3rd one will discourse the consequence of submerged edifices on societal life and the agencies of transit. The 4th will discourse the stuffs used, ways of edifice and particular demands. The fifth will present the jobs which face the submerged edifices. The 6th will demo the airing systems that are used. The 7th, will be illustrations of bing and approaching submerged edifices that make the reader able to visualise the thought good, and able to link all the parts of study together. Finally, the decision will back up and urge edifice and life underwater to diminish congestion and pollution on the surface of the Earth. 1. Introduction What are submerged edifices? Harmonizing to Dr. Khaled Abdelhady ( Professor in architecture technology, Shoubra University ) , submerged edifices are constructions built submerged for different intents each harmonizing to the type of edifice constructed ( personal communicating, 2010 ) . It all started in the 1960 ‘s by Jacques Cousteau ‘s squad in the signifier of submerged research Stationss ( submerged home ground, 2006 ) . Submerged edifices already exist, but have you of all time thought approximately traveling to an underwater edifice? Underwater edifice is the future foundation that has a great impact on the environment, we will be confronting some jobs while using this engineering but if we win in accomplishing it, it will be advantageous to our environment as it gets populated. It is true what was written in the â€Å" Evolo † magazine: â€Å" Approximately 71 % of the Earth ‘s surface is ocean, even more if clime alteration has its manner ; hence it is merely natural patterned advance that we will dwell the seas someday. † ( Water-Scraper: Underwater Architecture, 2010 ) .1.1 Background on submerged edifice typesWhen Dr. Khaled Abdelhady was asked about the types of underwater edifices he talked about the undermentioned types:1.1.1 Infra StructuresHe said that infra constructions are termss of edifices made under the H2O to allow the edifice itself above the H2O, for illustration the Bridgess linking metropoliss like the aureate gate span shown in figure 1.1 when you can see the base of span placed under the H2O ( personal communication,2010 ) . Figure 1.1: Aureate gate span ( beginning: www.google.com )1.1.2 Research centresSecond, Dr. Khaled talked about the research centres underwater. He said that there are two types of centres, foremost is an submerged lifes research centre which examine and observe animals submerged, and 2nd there are scientific centres which search for crude oil in the underside of seas and oceans ( personal communicating, 2010 )1.1.3 TunnelsAs for submerged tunnels Dr. Khaled Said they are passage ways constructed underwater. There is a type made for cyberspace chief overseas telegrams to be divided all over the universe, telephone lines, and others. Other type is made for autos to travel through submerged channels but for short distance rivers or H2O transitions like tunnel â€Å" Ahmed Hamdi † at the Suez Canal in Egypt ( personal communicating, 2010 ) .1.1.4 MuseumsAs for museums underwater, Dr. Khaled said there are 2 types, foremost one are museums made to see the submerged lifes without holding to travel through the dangers of diving and for really old grownups to be able to see them excessively, 2nd there are museums made to see the old sunken memorials, why underwater? So that you can see them they exact manner they were found in a beautiful originative manner. And it has already been constructed like in â€Å" Vasa Museum † in Stockholm ( personal communicating, 2010 ) .1.1.5 Hotels eating houses and amusementsAnother type that Dr. Khaled Abdelhady talked about was the amusement types of edifices. There are hotels, watering place, and eating houses built underwater so that people could hold a nice a holiday, a massage or a repast while watching the fishes and animals underwater. There are besides games made underwater like in Disney land roller coaster as shown in figure 1.2 when you can see people acquiring into the H2O while on the roller coaster ( personal communicating, 2010 ) . Figure 1.2: Disney land roller coaster ( Beginning: www.google.com )1.2 Advantage and credence of submerged edificesUnderwater edifices have a batch of advantages to people in Egypt. It will take down the crowded topographic points above land. It will increase the engineering use to be able to construct it. It will assist better touristry as people will come from all over the universe for amusement under the ruddy sea, and enjoyment of the amazing legion sorts of fishes and corals, and in same clip conserve the corals from being touched and hurt by people plunging. After inquiring a big figure of people if they would accept traveling to an submerged metropolis for amusement, holiday or touristry, it was surprising that most people accepted the thought. This means that if the thought really gets complete, it will be widely spread between people so rapidly and it will be successful in Egypt. And as you can see in figure 1.3 the figure of people accepting is about trebling the figure of people declining. Figure 1.3: Chart shows the figure of the credence and declining people3. Social facetsOvercrowding is considered the universe ‘s job, which is turning invariably and leads to many other jobs. This serious quandary prompted people to believe about the colonisation of the oceans, which led them to believe about the submerged edifices. As we know, H2O covers 70 % of the Earth ‘s surface, while land countries form a really little per centum. Taking a expression at the Earth from outer infinite, we will happen that the bluish colour dominates, and this will raise a batch of inquiries about how to work these countries. From this point, people begin to analyze the possibility of edifice underwater and do usage of such great surfaces. Let ‘s happen out if people will welcome the thought of life underwater in the hereafter, or it will be a useless undertaking. Due to high cost, these submerged edifices will be limited to a certain degree of people, and may be considered as a sort of prosperity. However, if we take into history that the engineering progresss, so there will be a manner to cut down the cost. But if complete metropoliss were built submerged, would people accept such alteration in their life. Some people can non populate without the Sun and do non conceive of themselves in a topographic point slightly isolated. Others want truly to seek this new life, and bask the composure and the glorious vision. In decision, populating underwater may go a world if its benefits overcome its troubles and jobs.3.1 Means of transitAfter seeking for the possible agencies of transit to populate under H2O, it was found that there are two possibilities. First, as many people will believe, pigboats would function as the chief mean of transit. For illustration, believing about its cost and pertinence, we will happen that it is the suited 1. Let ‘s move to the other possibility, at a larger graduated table, and speak about submerged tunnels. There are some bing submerged tunnels, which would be really effectual to achieve a certain submerged edifice or complete metropolis in the hereafter. For illustration, in Dubai, Hydropolis is an submerged hotel, but it is still under building. As it is described in figure 3.1, the developers of this undertaking explains: â€Å" It will include three elements: the land station, where invitees will be welcomed, the connecting tunnel, which will transport people by train to the chief country of the hotel, and the 220 suites within the undersea leisure composite. â€Å" ( Joachim Hauser, N.D. ) . Figure 3.1: The land station of Hydropolis ( Source: Design construct, ND. )4. Construction and construction facets4.1 The stuff usedA Although many stuffs exist for edifice, the 1 that meet the demands with the lowest costs are to be chosen. At this degree the cost will be minimized. . When taking the stuffs to be used in the building, it is of import to guarantee that the weight bound is non exceeded. ( Carl T.F. Ross & A ; Mark El-Hajj†¦ ) The chief stuff used for building underwater was a particular type of steel and acrylic. The acrylic stuff is used chiefly for visibleness, while the steel is used for supports ( supports ) . ( Carl T.F. Ross & A ; Mark El-Hajj†¦ ) High strength steel is used as it is comparatively inexpensive, and has its high output strength. It is non besides a good music director of electricity and heat. It is a high corrosion opposition. ( Carl T.F. Ross & A ; Mark El-Hajj†¦ ) A Acrylic stuff is used alternatively of glass ; It is better than glass due to being less dense, and it is besides has higher impact strength than the glass. Acrylic gives the natural size and colourss of the environing stuffs than glass. It is besides good dielectric of electricity which is good in seeking the wellness and safety of clients and submerged animals. ( Carl T.F. Ross & A ; Mark El-Hajj†¦ )4.2 ConstructionIt is known that the rewards for submerged building would be greater than on land building, due to the trouble faced during the on the job underwater. Another job would originate ; the edifice is big in size. For work outing these jobs, they divide the edifice into parts and edifice each portion on land so piece them under the H2O. ( Carl T.F. Ross & A ; Mark El-Hajj, †¦ †¦ †¦ .. )4.3 CareThe care procedure is a dearly-won procedure particularly when covering with an submerged care. The below figure shows us how this job can be solved, by spliting t he edifice into parts that can be separated from the whole edifice ; these parts can be transferred to set down so that a cheaper care can take topographic point. ( Carl T.F. Ross & A ; Mark El-Hajj†¦ ) Figure 4.1: The care procedure ( Beginning: Carl T.F. Ross & A ; Mark El-Hajj ) The crystalline portion of the edifice should be ever clean, so that the clients can see the marine clearly in all the clip. This state of affairs can be achieved by an machine-controlled system which uses a ego cleaning surfacing known as the smart stuff. ( Carl T.F. Ross & A ; Mark El-Hajj†¦ )5 Problem which face underwater edifice5.1 CostConstructing under H2O is a really expensive procedure due to the machines, instruments and skilled workers. Constructing under H2O besides contains some of public assistance as figures ( 5.1, 5.2 ) illustrate and it needs to immense budget. Figure 5.1: Example of under H2O ‘s public assistance ( Beginning: blog.hotelclub.com/top-five-underwater-hotels/ ) â€Å" Dreams, nevertheless fabulous, remain unrealized without the hard currency to back up the committedness ; the hardest portion of the procedure was happening sponsorship to the melody of a‚ ¬550m.That ‘s what brought me to Dubai. Still, it was a conflict which took two-and-a-half old ages and proved tougher than developing the undertaking itself. No bank would pay such an sum. It ‘s a hazardous investing, as there are no pilots. We had to convert investors that it is safe and will convey returns on investing. † ( Hauser, ND ) , so companies accept to co-operate with its challenger to finish under H2O edifice undertaking.5.2 The job of ErosionErosionA is the procedure ofA weatheringA and conveyance of solids ( deposit, A dirt, A rockA and other atoms ) in the natural environment or their beginning and deposits them elsewhere. It normally occurs due toA transportA by air current, H2O, or ice so applied scientists should take the appropriate stuffs for u nder H2O edifice.5.3 The location of crude oilFigure 5.2 shows that any accident may go on in the sea to the boring machines and machinery for seeking for oil or to any ship in the sea may harm the design of the edifice and it is out of control. Figure 5.2: The accident of the boring machine ( Beginning: hypertext transfer protocol: //Oc-Po/Petroleum-from-the Ocean.htmlhttp: //www.waterencyclopedia.com hypertext transfer protocol: //www.waterencyclopedia.comHYPERLINK â€Å" hypertext transfer protocol: //blog.hotelclub.com/top-five-underwater-hotels/ † HYPERLINK â€Å" hypertext transfer protocol: //blog.hotelclub.com/top-five-underwater-hotels/ † hypertext transfer protocol: //www.waterencyclopedia.comunderwater-hotels/ )5.4 The job of heat of H2OThe temperature of the H2O is extremely variable over the surface of the H2O, it is heated from the surface downward by sunshine, but at depth most of the H2O is really cold. ( Martha R.A Scott, ND )5.5 The job of force per unit areaPressure plays a large function in act uponing the foundations of the edifice besides workers face troubles either during the building procedure or during the care procedure.6. Environmental edifice facetsNo uncertainty that the first thin g that comes in our head while speaking about submerged edifices is the job of airing. Ventilation is defined as a: † procedure of providing fresh air to an enclosed infinite and taking from it air contaminated by olfactory properties, gases, or smoke â€Å" . Therefore, there must be a beginning of renewable air that helps in external respiration, and acquiring rid of unwanted gases, like C dioxide and others. Let ‘s research a solution, for the airing job, that was applied while constructing Holland tunnel, an submerged tunnel. Tunnels, specifically, have a great job with airing, due to gases produced by trains and cars. This job was addressed by Clifford Holland, the tunnel ‘s interior decorator. His purpose was to happen ways to unclutter exhaust exhausts and pump in fresh air, accomplishing this by utilizing airing towers, like the one illustrated in figure 5.1, and fans to travel air in and out. Finally, air can be renewed every 90 seconds. ( Howstuffworks, ND. ) Figure 6.1: Inside a Holland Tunnel airing tower ( Beginning: Eric and Edith Matson, ND. ) The airing systems that can be applied while edifice, can be divided into two methods: natural airing and mechanical airing. Natural airing depends on an unfastened window if the architecture permits, so it can non be used in submerged edifices. Therefore, mechanical airing is applied to air out these edifices. The most of import thing is the manner to acquire O needed for take a breathing. Breathing under H2O could go on in several ways ; such as hydrolysing the sea H2O, change by reversaling osmosis, or suctioning methods through air pumps. ( Chamberland, ND. ) . Oxygen can be extracted from saltwater since people will populate underwater, and it will be a practical method. Rearward osmosis is an effectual method used in H2O intervention ; and in the hereafter it will be used to acquire O, while populating underwater. Suctioning O, utilizing air pumps, would assist in both acquiring O and supplying good airing.7. Examples7.1 Dubai Underwater HotelIt is still under development. The hotel location will be 33 pess submerged. Its entire cost is over $ 550 million. The land station will be connected with the submerged subdivision with a 515 metre long tunnel through which an automatic train will transport people to the submerged hotel. It is 260 hectares country consisted of 220 suits bubble s haped 20 metres underwater. The hotel will besides hold several security steps. It has a series of watertight doors in instance of any ecstasy. It will besides hold its ain missile defensive system in instance of any terrorist onslaught.7.2 UNDERSEA RESORTS- Poseidon Mystery IslandThe thought was for the American applied scientist Bruce Jones. The Poseidon Resort ‘s Mystery Island shown in figure 7.1 could be reached by lift. It is a 1.1 million square pes, 40 pess under H2O. Room standard country is 550 square pes. ( wayfaring,2007 ) . The budget of the undertaking is $ 100 million. Figure 7.1: Poseidon Mystery Island ( Source: www.wayfaring.info )7.3 Ithaa underwater eating houseIt is the 1st of its sort in the universe. It is 16 pess below the surface of Indian Ocean. It is encased in clear acrylic. The ithaa eating house can be reached by a wooden paseo shown in figure 6.2 from over the H2O. It was difficult to construct it on the beach of rangali due to proficient challenge, limited resources and quality jobs. ( Wikipedia, 2010 ) . It was constructed in Singapore. Its building began in May 2004, and it was completed in October 2004 including installing of the acrylic arches, air conditioning and electric canals. Its life span is 20 old ages. Figure 7.2: Ithaa underwater eating house ( Beginning: World Wide Web. Wikipedia.com )7.4 Jules Undersea LodgeIt is the universe ‘s first submerged hotel, originally built in the early 1970s. It was opened to the populace in 1986. ( hotelclub,2007 ) .The entryway to the hotel is 21 pess underwater on the sea floor. The Lodge is to the full stocked with tight air.

Case Study- Vector Aeromotive Corporation - 1685 Words

No 3. The Extended Case Study- Vector Aeromotive Corporation Zhenhua Rui 09/20/2010 Vector Aeromotive Corporation was a company which designed, manufactured and sold exotic sports cars. Vector was the only U.S.-based manufacture of exotic sports cars, and his major competitors were Ferrari and Lamborghini. Gerry Wiegert is the President and founder of this company. In 1987, the board of directors was formed with three directors. This case shows events happening between the board and President Gerry. In March 1993, the company’s financial position was critical, and Vector’s board decided to ask President Gerry to resign from the company due to his bad performance. But Gerry declined to resign and declare a war against board of directors.†¦show more content†¦All these actions or issues together caused a serious conflict between the board and president. Finally, the board tried to remove the President Gerry, and Gerry rejected to resign. The bad situation of Vector Company was not totally caused by Gerry’s fault. There were some problem s with the board. Seeing from three board member’s background, Board members were not independent from managers. For example, John Pope was CFO of Vectors from 1998 to 1990. Barry Rosengrant was consultants to vectors and business associates of Gerry for many years. Gerry was also the board chairman. Three members were all related to the company or President Gerry. This relationship may influence the board’s action in the future. Research evidence shows that higher independence is associated with lower incidence of accounting fraud. In response to president’s issues, the board also took some action against President Gerry. Some of actions are not appropriate or timely. 1) TheShow MoreRelatedEssay about Vector Aeromotive Corporation Case Study1206 Words   |  5 Pagesthe following duties: 1) duty of care – duty to make/delegate decisions in an informed way; 2) duty of loyalty – duty to advance corporate over personal interests; 3) duty of good faith – duty to be faithful and devoted to the interests of the corporation and its shareholders; 4) duty not to â€Å"waste† – duty to avoid deliberate destruction of shareholder value. There is no reason to believe that the duties of Vector’s board should be any different. The major conflict between Vector’s board and its